Programme


1 Wednesday 13th December 2017

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Inaugural Speech 9:00-9:05 Prof Stephen G. Ward Head of Department of Pharmacy & Pharmacology, University of Bath, Bath, UK

Welcome message 9:05-9:15 Dr Charareh Pourzand (University of Bath) & Dr Caoimhe M. R. Fahy (Royal United Hospitals, Bath, UK)

First Session (9:15-10:30 AM)

SKIN PHOTOSENSITIVITY, AGEING & PHOTOPROTECTION I Chairs: (1) Prof Paul J. Matts (London, UK); (2) Dr Caoimhe M. R. Fahy (Bath, UK)

IL1 9:15- 9:40 Rachel Watson (Manchester, UK) ‘Skin ageing and repair’

IL2 9:40- 10:05 Abigail Langton (Manchester, UK) ‘Ageing in skin of colour’ IL3 10:05 -10:30 Antony R. Young (London, UK) ‘Sunscreen Photoprotection: Lessons from Africa’

10:30-10:55 COFFEE BREAK

Second Session (10:55-12:45 AM)

SKIN PHOTOSENSITIVITY, AGEING & PHOTOPROTECTION II

Chair: (1) Prof Paul J Matts (London, UK); (2) Dr Ian S Blagbrough (Bath, UK)

IL4 10:55-11:20 Rex M Tyrrell (Bath, UK) “Solar UVA and oxidative stress: Do exogenous antioxidants enhance skin protection?”

OP1 11:20- 11:40 Karl Lawrence (London, UK) “Marine mycsporine like amino acids (MAA) – biocompatible sunscreens from nature”

OP2 11:40-12:00 Ian S Blagbrough (Bath, UK) “Modern Phytochemistry Research on Hydroxycoumarin Biosynthetic Pathways with Potential for Skin Photoprotection”

IL5 12:00- 12:25 Julia Li Zhong (Chongqing, China) “UVA irradiation releases antioxidants for photoprotection”

OP3 12:25- 12:45 Wang Mei (Chongqing, China) “TAZ is required to sustain redox homeostasis in skin and acts by regulating the HO-1mediated antioxidant response.


2 12:45- 13:45 Lunch Break and Poster Session

Third Session (13:45-15:45):

UNDERSTANDING MECHANISMS UNDERLYING NON-MELANOMA SKIN CARCINOGENESIS Chairs: (1) Dr Christopher Lovell (Bath, UK); (2) Dr Olivier Reelfs (Bath, UK)

IL6 13:45-14:15 Peter Karran (London, UK) “Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA”

OP4 14:15-14:35 Matthew Caley (London, UK) “Tumour associated macrophage recruitment in squamous cell carcinoma”

IL7 14:35-15:00 Sarah Allinson (Lancaster, UK) ‘The direct and indirect activation of the DNA damage response by UVA’

IL8 15:00-15:25 Joerg W. Bartsch (Marburg, Germany) “The role Nrf2 in skin cancer”

OP5 15:25-15:45 O. Reelfs (Bath, UK) Topical iron chelation therapy for the treatment of skin cancer and UVA-sensitive ironrelated disorders

15:45- 16:05 Coffee Break

Fourth Session (16:05-18:30):

SKIN INFLAMMATORY DISORDERS: CURRENT INNOVATIONS IN THERAPY AND FUTURE CHALLENGES TO OVERCOME Chairs: (1) Prof Neil McHugh (Bath, UK); (2) Dr Sarah Woodrow (Bath, UK)

IL9 16:05- 16:30 Padraic Fallon (Dublin, Ireland) “Atopic dermatitis: tales of mice and men.”

IL10 16:30-16:55 Zarif Jabbar_Lopez (London, UK) ‘Water hardness and skin: how hard can it be?’

OP6 16:55- 17:10 Amy Foulkes (Manchester, UK) ‘Great expectations: can we deliver better patient outcomes?”

IL11 17:10-17:35 Ryan O’Shaughnessy (London, UK) ‘Elucidating multiple roles for AKT1 in skin barrier function and skin disease’

OP7 17:35-17:55 John Pauling (Bath, UK) ‘Current therapies and future challenges for the therapy of scleroderma’

OP8 17:55-18:15 William Tillett (Bath, UK) ‘Current therapies and future challenges for the therapy of psoriatic arthritis’

19:30- 23:30 Dinner Reception

This meeting has been sponsored by the following companies; AbbVie, Cosmetics Journal, Janssen, La Roche-Posay, Photonics Ltd, Sanofi Genzyme & Vision & Cosmetics


3 Skin@Bath Network Symposium Old Theatre Royal, Bath, UK

Scientific Program


Thursday 14th December 2017 ___________________________________________________________

Fifth Session (8:30-10:30):

SKIN PHOTOSENSITIVITY, AGEING & PHOTOPROTECTION III Chair: Prof Ioav Cabantchik (Jerusalem, Israel)

IL12 8:30-9:00 Robert C Hider (London, UK) ‘Therapeutic Iron chelation’

IL13 9:00-9:25 Estelle Loing (Quebec, Canada) “Fight IR-induced aging: novel concept to skin photoprotection”

IL14 9:25-9:50 Xi Huang (Montvale, USA) “Treating dark circle under the eye by addressing iron in ferritin and hemoglobin”

OP9 9:50- 10:10 Catherine Bonn (Newcastle, UK) “Broad protection in Sun Care”

OP10 10:10-10:30 Charareh Pourzand (Bath, UK) “Targeting iron and oxidative stress for skin photoprotection”

10:30-10:50 Coffee Break

Sixth Session (10:50 – 13:15):

INNOVATIONS IN TOPICAL DRUG DELIVERY (SKIN/NAIL) Chairs: (1) Dr Shohre Nabahi (Swindon, UK); (2) Prof Richard H. Guy (Bath, UK)

IL15 10:50-11:15 Adrian F. Davis (Surrey, UK) “Kligman Cosmeceutical Concepts: Learnings from Cosmetic Science”

IL16 11:15-11:40 Adrian Williams (Reading, UK) “You can’t put that in there!”: Passive bio-macromolecule delivery to the skin IL17 11:40-12:05 Ryan F. Donnelly (Belfast, Northern Ireland) “Microneedle Array Patches for Systemic Delivery of High-dose Drugs”

IL18 12:05-12:30 Richard H. Guy (Bath, UK) “The pharmacokinetics of drug delivery to the skin”

IL19 12:30-12:55 Stuart Jones (London, UK) “Using nanomaterials to modify drug deposition profiles in the skin”


4 OP11 12:55- 13:15 Begona Delgado-Charro (Bath, UK) “Topical treatment of nail diseases. A challenging endeavour”

13:15- 14:00 Lunch Break and Poster Session

Seventh Session (14:00-16:10):

SQUAMOUS CARCINOGENESIS & CURRENT INNOVATIONS IN PHOTODYNAMIC THERAPY OF NONMELANOMA SKIN CANCER Chairs: (1) Prof Paul Winyard (Exeter, UK); Dr Ian M. Eggleston (Bath, UK)

IL20 14:00 -14:30 Irene M. Leigh (Dundee, UK) “Molecular mechanisms of squamous carcinogenesis”

IL21 14:30-14:55 Paul Winyard (Exeter, UK) “Changes in cellular redox status, and redox responses to photodynamic irradiation, under standard oxygen cell culture conditions versus physioxia: are most mammalian cell culture experiments done at irrelevant oxygen concentrations?”

IL22 14:55-15:20 Alison Curnow (Exeter, UK; Cornwal, UK) “The Mechanism of Action of Dermatological PDT”

IL23 15:20-15:45 Ewan Eadie (Dundee, UK) “Novel Photodynamic Therapy Light Sources”

IL24 15:45-16:10 Ben Novak (Leverkusen, Germany) “Development and clinical application of a nanoemulsion-based drug delivery system for topical ALA-PDT”


Eighth Session (16:10-18:05):

INNOVATIONS IN WOUND DRESSING, WOUND HEALING AND FUNGAL SKIN INFECTION MODELS Chair: Prof Michael R.W. Brown (Dundee, UK)

IL25 16:10- 16:35 Toby Jenkins (Bath, UK) “Intelligent wound dressing for therapeutic and diagnostic management of wound infection”

16:35-17:00 Coffee Break

IL26 17:00-17:25 Keith Harding (Cardiff, UK) “Innovation in Wales – Opportunities and Challenges”

OP12 17:25-17:45 Albert Bolhuis (Bath, UK) “Development of fungal skin infection models”

OP13 17:45-18:05 Ian M Eggleston (Bath, UK) “Targeted agents for photodynamic therapy”

Concluding Remarks

18:05-18:15 Dr Charareh Pourzand (University of Bath) & Dr Caoimhe M. R. Fahy (Royal United Hospitals, Bath, UK) This meeting has been sponsored by the following companies; AbbVie, Cosmetics Journal, Janssen, La Roche-Posay, Photonics Ltd, Sanofi Genzyme & Vision & Cosmetics


5 POSTER Sessions: Wednesday 13th and Thursday 13th at lunch break:

P1 D. Beiki, T. Radka, O. Reelfs, I.M. Eggleston and C. Pourzand (Bath, UK) Harnessing ultraviolet a-induced labile iron release to improve the effectiveness of aminolevulinate-based photodynamic therapy (ALA-PDT) of skin cells

P2 G. Cami-Kobeci, M. Mushtaque and S.M. Husbands (Bath, UK) Towards new treatments for Atopic Eczema (AE)

P3 B.B. Gokce, S.F. Cordery, R.H. Guy, S. Gungor (Istanbul, UK) G2-PAMAM dendrimer-based nanocarriers for delivery and targeting of adapalene to hair follicles

P4 A. Hampshire, O. Reelfs, C. Pourzand, I.M. Eggleston (Bath, UK) Light-activated caged iron chelators for skin photoprotection

P5 Ka H. H., M.B. Delgado-Charro, A. Bolhuis (Bath, UK) Development of a Skin Infection Model to Study Fungal Adherence and Invasion

P6 M. Malerba, J.R.R. Mathieu, S. Louis, S. Cuvellier, C. Peyssonnaux (Paris, France) Epidermal hepcidin is protective against group A Streptococcus infection and systemic bacterial spread

P7 A. Pensado, K.A.J White, A.L. Bunge, R.H. Guy, M.B. Delgado-Charro (Bath, UK) Quantification of transdermal input rate by in vitro release, skin permeation and tape stripping experiments

P8 M. M. Saleh, A. Woods, R. Harvey, S. A. Jones (London, UK) Nanostructured vitamin E phosphate: Characterising its cutaneous permeation and interaction with skin lipids

P9 M.A.M. Tabosa, K.A.J. White, M.B. Delgado-Charro, R.H. Guy (Bath, UK) Probing drug pharmacokinetics in the skin in vivo and in vitro P10 A. Tewari, R. Sarkany, A.R. Young Novel approaches for photoprotection via genome studies

P11 M. Wang, Y. Guo, L. Chang , Yang X, Zhong J.L. (Chongqing, China) TAZ is required to sustain redox homeostasis in skin and acts by regulating the HO-1mediated antioxidant response.